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Related post: intercourse (while having an active discharge). A few days later the arthritis began in the wrist and hip. He denied ever having had a chancre or rash. He never had rheumatism, malaria, typhoid fever, nor any trouble with joints, teeth, eyes, ears or sinuses ; did have sore throat when j^ounger. Family history. — His father died of carcinoma of the breast. His mother, brothers, and sisters living and well. No tuberculosis or lues traceable in family. General condition. — The temperature varied from 99.5° to 103° F. with increased pulse and res- piration. Has had chills and chilly sensation ; in- somnia ; dry coated tongue, parched lips, crying v/ith pain ; restless, nervous, and slightly delirious at night during sleep. Patient was septic in ap- pearance. Laboratory findings. — The gonorrhea blood complement fixation tests were all positive from various laboratory reports. The urethral smear was positive for gonococci. The blood Wassermann and Noguchi tests were negative from three dif- ferent laboratory reports. Negative blood smears for malaria. Negative Widal reaction (several times). On early blood cultures, no growth was obtained. Recent blood cultures have not yet been reported. Secondary anemia of mild grade present, due to the general gonorrheal infection and meta- static involvement. Hemoglobin, 75 per cent. ; white blood cells, 16,400: Polymorphonuclear, 84: .small mononuclear, 13: large mononuclear, i; eosino- phile, 2; red blood cells, 4,160,000. Janu- ary 27, 1919: trace of albumin found in the urine. All qualitative tests for indican, sugar, diacetic acid, and acetone negative. Buy Benazepril / Amlodipine A few red blood cells ; a few pus cells ; ammonium urates ; total solids, thirty-five grams to the litre ; urea, 1.4 per cent. ; specific grav- ity, 1.05; no casts; some squamous cells. The reac- tion of the urine was alkaline (due to the medica- tion) on February 3, 1919, ]). m.. amber, 1.015 speci- fic gravity ; some indican, very faint trace albumin : some white blood cells ; some bladder epithelial cells ; many cylindroids ; few uric acid crystals. Febru- •Rcad before New Jersey State Medicyl Society, Spring Lake N. J., June 24, 1919 ary 4, 1919, a. m., amber; 1.013 specific gravity; acid; trace of albumin; indican; many white blood cells; few red blood cells; some bladder epithelial cells ; very few hyaline casts and many cylindroids ; some amorphous urates. The blood pressure : Sys- tolic, 1 10 ; diastolic, 74. Physical examination. — The heart sounds were weakened in tone, and at times a faint murmur was heard, especially after deep breathing and then holding breath: possibly due to the anemia or a beginning acute endocardial or myocardial involve- ment. Except for a few scattered rales, the lung condition was negative. A slight cough existed which was due to an associated tracheobronchitis, or myocardial weakness. Treatment. — Dial,^ ciba, or barbital, and M. S. one eighth to a quarter of a grain, given on several occasions as required. The patient has received complete and absolute rest in bed for three weeks with Blaud's pills for the anemia. Pure santal oil in capsules and argyrol injections for the local con- dition, which was improving nicely. Plenty of wa- ter to drink. An aperient water for the bowels. Also heavy mineral oil and alkaline rectal enemas — both evacuating and irrigating ; polyvalent antigonococcic serum intramuscularly and intravenously ; gono- coccus vaccine hypodermically and intramuscularly ; small doses of mercury and large doses of syrup. Ferric iodide for varying periods. The most satis- factory and most rapid relief from pain and im- provement was noticed after the combined use of the vaccine and one large intravenous injection of the antigonococcic serum (fifty c.c), given when he was in a very septic condition and suffering greatly. The relief and improvement were almost as though by magic. Dr. Alfred C. Wood, of the Uni- versity of Pennsylvania, saw the patient with me and believed that cause and effect in this case would indicate the further use of specific serum vaccine therapy. No other medication received at the time could possibly have had such beneficial effect. A few days ago x ray examination was advised to decide whether there is an arthritis, an osteo- arthritis, or effusion in the joint, and his removal to the hospital was urged for this purpose and for the possible relief of pain b}' Buck's extension or plaster of paris splint, or any possible operative mterference that may later be necessary, in the opinion of the surgeon. About a week after the initial administration of the pol)^v-alent antigonococcic senmi, the patient had soiue urticaria with marked itching, which passed away after a few days. Before he received the large scrum doses, he had received a small injection of the serum as a desensitizing dose. This prevented any marked anaphylactic serum reaction. After the large intravenous injection of the serum, he received fifteen minims of adrenalin solution and a very small dose of atropine, to ward ofi any pos- sible afterefifects. However, the patient took the specific therapy without any untoward results and with considerable improvement until lately, when his pain returned after the specific treatment had ^Dial — diallylbarbituric acid. Sedative and hypnotic but not nar- cotic. Dose, one and one half to four and one half grains. January 3. 1920.] GOLDSTEIN: METASTATIC GONORRHEA. 23 been discarded for several days, and he was ad- vised to go to the hospital for the x ray studies. A later report showed that after the antigonococcic serum and mixed gonococcus vaccine were stopped, and while he was in the hospital, there developed z marked inflammation of the knee, which I believe could have been prevented by the continued use of the vaccine and serum. Careful measurement was made of the urine out- put and of the intake of all fluids. The urinary output was satisfactory and his kidneys at no time gave us any concern. Locally for the relief of pain in the joint I ordered a hot water bottle, hot turpentine stupes, tincture of iodine painted on the affected area, and the old reliable ointment contain- ing belladonna, mercury, and ichthyol at different times. I did not use calcium sulphide nor any of Related links: Suminat Nasal Spray, Purchase Cipro Online, Buy Cheap Evecare, amoxicillin purchase, 5 mg lexapro, buy clomid, Ibuprofen Vs Motrin, Buy Valtrex Online Canada, Tranexamic Acid Skin Care, Buy Effexor Xr Online
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