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Related post:
mining influence upon our conception of the origin and dis-
tribution of Buy Cheap Finast certain infectious Order Finast diseases. We know, for ex-
ample, bacteria, such as the bacilli of mouse septicaemia and
rouget, which, as regards appearance and pathogenic prop-
erties, are certainly very closely related. One is the cause
of a disease of swine in Europe, the other is occasionally
present in putrefactive substances and is fatal to mice and
pigeons. A still better illustration is furnished bv a large
group of diseases among animals, including some cattle dis-
eases ( Wildseucke of Bollinger), fowl cholera and swine
plague, which are caused by bacteria very closely related —
in fact, scarcely, if at all, distinguishable from one another.
Can the germ of one of these diseases produce epizootics of
another at any given moment and under certain conditions, Buy Finast
or are the barriers which separate these germs insurmount-
able ? If we admit the former — if, for instance, we grant that
fowl cholera can Purchase Finast give rise to Order Finast Online swine plague under certain
conditions — we evidently regard the germs of these diseases
simply as varieties of one species. If we regard the dis-
eases as wholly distinct and not convertible one into the
other, we must consider the respective germs as distinct
Without delaying to discuss these problems or express
any opinions which I may hold temporarily concerning them,
I pass on to the subject of this communication.
Several years Purchase Finast Online ago I presented a brief paper to this Sec-
tion in which I described a variety of the hog-cholera germ,
which presented the minor peculiarity of forming speedily
a membrane on the surface of liquid culture media, a feat-
ure not possessed by the hog-cholera germ found bv me in
1885. This fact, although of apparently slight significance
to-day, was of more importance at that lime, since our con-
ception of disease germs, formulated by Koch and his
school, endowed germs with Finast Tablets little if any ca[)acity to appear
under varying characters. Since that time, as I have
pointed out before, slight variability among disease germs
has been detected by many observers.
Early in 1889 an epizootic came under my observation
from which I obtained a bacillus departing still more from
the original type. It is beyond the .scope of this paper to
give in detail the biological, morphological, and pathogenic
characters of the hog-cholera bacillus. I must refer you to
the published reports of the Bureau of Animal Industry,
especially those of 188.5 and 1886, for this matter. I shall
simply refer to those points necessary to bring into relief
the differences between the two germs to be compared. I
shall designate the original germ of 1885, since found in a
large number of epizootics in ditt'erent parts of the country,
as bacillus a, that of 1889 as bacillus (3. I should add that
neither of the germs has anything in common with the
swine-plague germ, which, in truth, belongs to a wholly dif-
ferent group of bacteria.
If I were asked to state in a general way the ditl'crence
between bacillus o and bacillus /J, I should say that Finast 5mg the
bacillus /3 was in every way nearer the saprophytic stage
than a. This is readily apparent from the fcjllowing con-
siderations :
On gelatin plates, ft grows more rapidly, its deep as
well as Buy Finast Online surface colonies attain much larger dimensions than
those of a, the surface colonies frequently reaching a di-
ameter of four to five niillimetres, while those of a usually
show little, if any, tendency to spread out. In alkaline
bouillon with peptone, a barely clouds the liquid, while ji
produces a high degree of turbidity. In other culture
media there are no differences perceptible. Bacillus j3 in
cultures appears slightly larger than a ; in the tissues of ani-
mals, however, the difference in size is not appreciable.
Bacillus /3 has ranch less pathogenic power than a. Pigs
are readily infected with a fatal disease when fed with bou-
illon cultures of a. When fed with cultures of (i they be-
come very sick, but recover within a week. Only one suc-
cumbed to feeding, and in this case the bacilli had pene-
trated the body only as far as the mesenteric glands.
When we come to smaller experimental animals, the rab-
bit is perhaps the best to illustrate the differences between
a and /3.
When inoculated subcutaneously with bacillus a (as lit-
tle as one millionth of a c. c. of a bouillon culture has been
sufficient to produce a fatal disease), the rabbit dies within
from seven to ten days. The temperature rises 4° to 5° F.
from three to four days before death. At the autopsy the
spleen is found very large, due to blood engorgement; in the
liver are small foci of yellowish necrotic tissue. The kidneys
have undergone parenchymatous inflammation. The urine

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