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Dissolution and Evolution and the Science of Medicine: An
Attempt to Co-ordinate the Necessary Facts of Pathology
and to Establish the First Principles of Treatment. By 0.
PiTFiELD Mitchell, Member of the Royal College of Sur-
geons, England, etc. London : Longmans, Green, & Co.,
1888. Pp. xvi-246.
Ambition is a quality Allopurinol 400 Mg which always excites a certain meed of
admiration, even when it leads to overtemerous exploits ; and
no more ambitious attempt has come within our ken than this
effort to apply the arguments of Herbert Spencer's synthetic
philosophy to the uncertainties of pathology and ietiology, since
it involves not only an ingenious Allopurinol Price sophistry in reconciling known
facts to a preconceived hypothesis, but an almost creative genius
in inventing pathogenic doctrines to support theoretical postu-
lates. The author's fundamental assumption is that disease is
"a disintegration of matter caused by an absorption of sur-
rounding energy," and, if all observed phenomena do not at
first sight harmonize with this assumption, tant pis pour les
fails. Thus, although the phenomena of Allopurinol 200 Mg inflammation and sup-
786
NEW INVKSTIONS.— MISCELLANY.
[N. Y. Mbd. Jocb.,
|Miriitiitii conli'Hst'dly ilo not n|»|)i«iir to conform to tlio writer's
(lolinilioii, it is ex|>laini»(l tliiit wimt \vt> really hoo Ih nn incronso
in the niiinbor of " tlie nioro Hitnple nnd Ioph Hpuriali/ed iinitH,
the whito corpuscU'H," and that, Hinco tho»c do not play in tlioir
oxtravasali'd i-tato tho special rAlo of hlood U'lKvx'ytfs. tliuir
ni'pitivo '• attrilmlos aro nndorslood to Hi;;nify do|,'«'ni'ratlvo
:i>s."' In consistoncy with this oxenonis, the Hocrnl ions of
tho nianiinary and oilier >.Mands are elas-ed ainonj; products of
dirt«iolntion, while, on the other hand, tatintiltration '\i\ pseudo-
liypertrophio ]>nralysis is regarded as an ovolutionul ur integra-
tive process. The diplithoritie exudation is disposed of as nn
oxnmple of coagulation-necrosis, and we are told that all retro-
grade inetaniorphorses " imply an absorption of external en-
orgy," us do likewise scarlet fever, anthrax, tinea, ta'nia, pedic-
idi, itch, etc.
No existing theory concerning ncoplasmuta suits the author's
views, and, not having to swear in the words of either Virchow
or Wnldeyer, he launches the stnrtlingly original liypothesis
that the formation of tumors is an example of " asexual genesis"
from the natural ])lastids of the body, in all ])robability n rever-
sion to the primal type of reproduction of the Protozoa, attirra-
ing that "the tumor-developing i)oriod of life is the rei)rodiict-
ive period," and in support of this proposition citing "cancer
of Allopurinol 300 Mg Tablets the breast and nterns." lie furthermore " strongly suspects "
nn important relation between tumor-formation and high nutri-
tion and excess of food. This latter condition seems to play a
large and varied part in Ids etiological
philosophy, for he says that "both
pneumonia and phthisis arc initially
dependent on the action of pulmonary
arterial blood made irritant by the in-
gestion of superabundant, improper, or
impure food."
Our readers would hardly thank us
for following the chain of suppositions
through the mazes of neurology, alien-
ism, and other special tields of [)athology over which the author
roams in a desultory way, seasoning his obiter dicta with rather
too frequent repetitions of " perhaps," '' pres-umably," " not im-
probably," "in all likelihood," " it appears safe to infer," etc.
The specimens already given may suffice to justify the opinion
that the work is an ingenious but somewhat sophomorical essay,
bas.'d more upon insufficient closet Allopurinol 30 Mg study than upon practical
experience or thorough conversance with scientific literature.
BOOKS AND PAMPHLETS RECEIVED.
Proceedings of the New York Pathological Society. For the Year
1887. Pp. 212.
The Allopurinol 100 Mg Tablet Goulstonian Lectures (substance of) on Insanity in Relation to
Cardiac and Aortic Disease and Phthisis. Delivered before the Royal
College of Physicians of London, March, 1888. By W. Julius Mickle,
M. D., F. R. C. P. Lond., etc. [Reprinted from the " British Medical
Journal."] London: H. K. Lewis, 1888. Pp. 5 to Allopurinol 100 Mg 93.
New and Rare Drugs: Being a Concise Reference to the Uses,
Doses, and Preparations of some 250 of the Latest Introductions.
Fifth Edition. London: Christy & Co., May, 1888. Buy Allopurinol
Memorial Address, delivered before the Faculty and Students of
the College of Physicians and Surgeons on the First Anniversary of the
Death of Professor A. F. Erich. By George H. Rohe, M. D., Baltimore.

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